Enhanced activity localization and microscale dosimetry in alpha-emitter radiopharmaceutical therapy using integrated autoradiography and histological imaging
Abstract Alpha-emitter radiopharmaceutical therapy delivers highly localized radiation, offering potent therapeutic effects. However, microscale heterogeneity remains poorly characterized in vivo and may affect efficacy. This underscores the critical need for sub-organ dosimetry to better understand...
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| Main Authors: | Sandeep Sahota, Krystal A. Quirindongo, Joseph Piccolo, Anupriya Chhabra, Nouran Zaid, Simin Deveauxbray, Kenechukwu C. Charles-Obi, Brian Miller, Robert F. Hobbs, George Sgouros, Remco Bastiaannet |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-09277-4 |
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