Enhanced activity localization and microscale dosimetry in alpha-emitter radiopharmaceutical therapy using integrated autoradiography and histological imaging

Abstract Alpha-emitter radiopharmaceutical therapy delivers highly localized radiation, offering potent therapeutic effects. However, microscale heterogeneity remains poorly characterized in vivo and may affect efficacy. This underscores the critical need for sub-organ dosimetry to better understand...

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Bibliographic Details
Main Authors: Sandeep Sahota, Krystal A. Quirindongo, Joseph Piccolo, Anupriya Chhabra, Nouran Zaid, Simin Deveauxbray, Kenechukwu C. Charles-Obi, Brian Miller, Robert F. Hobbs, George Sgouros, Remco Bastiaannet
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-09277-4
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