Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-κB-mediated inflammation by regulating the PI3K/AKT/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model

Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-κB-mediated inflammation by regulating the PI3K/AKT/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Previous studies have reported that fucoidan can relieve obesity and hepatic steatosis in vivo, although the molecular mechanism remains unclear. This study aimed to explore the effec...

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Bibliographic Details
Main Authors: Xueru Chu, Xuan Wang, Keqing Feng, Yanzhen Bi, Yongning Xin, Shousheng Liu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Lipids in Health and Disease
Subjects:
Non-alcoholic fatty liver disease
Fucoidan
Spheroid
Lipid accumulation
Oxidative stress
Online Access:https://doi.org/10.1186/s12944-025-02483-z
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https://doi.org/10.1186/s12944-025-02483-z

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