Exosome-Modified AAV Gene Therapy Attenuates Autoimmune Hepatitis via Enhanced Regulatory T Cell Targeting and Immune Modulation

Exosome-Modified AAV Gene Therapy Attenuates Autoimmune Hepatitis via Enhanced Regulatory T Cell Targeting and Immune Modulation

Autoimmune hepatitis (AIH) is a chronic liver disorder driven by immune dysregulation, marked by reduced regulatory T cells (Tregs) and unchecked inflammation. Current therapies lack specificity and efficacy, necessitating novel approaches. This study explores gene therapy using exosome-associated a...

Full description

Saved in:
Bibliographic Details
Main Authors: Wenwei Shao, Weilin Huang, Yixuan Wang, Helin Sima, Kai Ma, Rongtao Chen, Heqiao Han, Yixuan Yang, Yuchen Bao, Xiaolei Pei, Lei Zhang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Microorganisms
Subjects:
autoimmune hepatitis
exosome-associated AAV
Foxp3
regulatory T cells
gene therapy
immune modulation
Online Access:https://www.mdpi.com/2076-2607/13/4/823
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2076-2607/13/4/823

Similar Items