Exploring the antimicrobial activity of pantothenamides against uropathogenic Escherichia coli

Exploring the antimicrobial activity of pantothenamides against uropathogenic Escherichia coli

ABSTRACT Metabolic processes required for bacterial pathogens to adapt in the host are potential targets for the development of much-needed new antimicrobial agents. The bacterial central metabolic enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) is required for the synthesis of essential isopr...

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Main Authors: Alicia A. DeColli, David J. Meyers, Arina Ranjit, James Paule, Erika Serrano-Diaz, Kimberly M. Bockley, Laura M. Ensign, Rana Rais, Caren L. Freel Meyers
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
CoA biosynthesis
pantothenamides
N5-Pan
uropathogenic E. coli
urinary tract infection
DXP synthase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03069-24
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https://journals.asm.org/doi/10.1128/spectrum.03069-24

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