Optimizing shared decision-making for risk-reducing mastectomy in women with Li–Fraumeni syndrome using patient-reported outcome measures

Optimizing shared decision-making for risk-reducing mastectomy in women with Li–Fraumeni syndrome using patient-reported outcome measures

Abstract Decisions regarding risk-reducing mastectomy (RRM) in women with Li–Fraumeni Syndrome (LFS) are challenged by unclear survival benefits and potential quality of life (QOL) impacts. We evaluated QOL in LFS women and identified factors associated with QOL outcomes in those who received RRM. L...

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Bibliographic Details
Main Authors: Natalia Polidorio, Renata L. Sandoval, Pâmela Bioni, Janina Pisani, Maria I. Achatz
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Breast cancer
Li–Fraumeni syndrome
Hereditary breast cancer
Risk-reducing mastectomy
BREAST-Q
Online Access:https://doi.org/10.1038/s41598-025-89068-z
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https://doi.org/10.1038/s41598-025-89068-z

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