GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons

GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons

Abstract The neural substrates of anxiety are poorly understood, which hinders treatment of anxiety disorders. Here we found, αCaMKII+ neurons in the ventral medial hypothalamic nucleus (VMH) responded to stressors with increased activity in male mice, both under physiological conditions and after r...

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Main Authors: Meng Zhang, Liu Yang, Xue Mi, Gonghui Hu, Yingchang Lu, Chen Wang, Jie Yang, Xiaomin Sun, Minglu Niu, Xianchao Li, Sihan Wang, Jingsai Zhang, Hanbing Yu, Yuyang Wang, Ming Yu, Nan Li, Yu Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59116-3
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https://doi.org/10.1038/s41467-025-59116-3

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