Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers

Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers

Background T-cell costimulation is crucial for an effective and sustained antitumor immune response, and inadequate expression of costimulatory ligands within tumors can impair T-cell function. Bispecific antibodies (bsAbs) targeting a tumor-associated antigen and the T-cell costimulatory receptor C...

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Main Authors: Manpreet Kaur, Starlynn C Clarke, Katherine E Harris, Nathan D Trinklein, Elaine C Chen, Katja Rüger, Udaya S Rangaswamy, Laura M Davison, Sebastian Moreno Arteaga, Imani Smith, Ruth Chu, Soumili Chattopadhyay, Mathias Rickert, Shelley Force Aldred
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e011323.full
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https://jitc.bmj.com/content/13/4/e011323.full

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