Expression of the cholesterol transporter SR-B1 in melanoma cells facilitates inflammatory signaling leading to reduced cholesterol synthesis

Expression of the cholesterol transporter SR-B1 in melanoma cells facilitates inflammatory signaling leading to reduced cholesterol synthesis

Scavenger receptor class B type 1 (SR-B1) is a cholesterol transporter, abundantly expressed in human melanoma, yet its precise role for melanoma progression is not fully understood. This study investigates the involvement of SR-B1 in cholesterol homeostasis of tumor cells and its implications for p...

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Bibliographic Details
Main Authors: Oliver Eckel, Madalina A. Mirea, Anna Gschwendtner, Martina Pistek, Katharina Kinslechner, Clemens Röhrl, Herbert Stangl, Markus Hengstschläger, Mario Mikula
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
HDL receptor
Cholesterol
S1P
HIF1A
Inflammation
BLT-1
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000338
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