Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction
Aim. This paper aimed to examine the chemoprotective actions of aqueous black tea extract (BTE) against nonalcoholic steatohepatitis- (NASH-) induced skeletal changes in rats. Material. Wistar rats (body wt. 155–175 g) of both sexes, aged 4–5 months, were randomly assigned to 3 groups; Group A (cont...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/426863 |
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| author | Subhra Karmakar Sangita Majumdar Anasuya Maiti Monalisa Choudhury Aniruddha Ghosh Asankur S. Das Chandan Mitra |
| author_facet | Subhra Karmakar Sangita Majumdar Anasuya Maiti Monalisa Choudhury Aniruddha Ghosh Asankur S. Das Chandan Mitra |
| author_sort | Subhra Karmakar |
| collection | DOAJ |
| description | Aim. This paper aimed to examine the chemoprotective actions of aqueous black tea extract (BTE) against nonalcoholic steatohepatitis- (NASH-) induced skeletal changes in rats. Material. Wistar rats (body wt. 155–175 g) of both sexes, aged 4–5 months, were randomly assigned to 3 groups; Group A (control), Group B (60% high-fat diet; HFD), and Group C (HFD + 2.5% BTE). Methods. Several urinary (calcium, phosphate, creatinine, and calcium-to-creatinine ratio) serum (alkaline phosphatase and serum tartrate-resistant acid phosphatase), and molecular markers of bone turnover (receptor activator of NF-κB ligand (RANKL), osteoprotegerin (OPG), and estrogen) were tested. Also, several bone parameters (bone density, bone tensile strength, bone mineral content, and bone histology) and calcium homeostasis were checked. Results. Results indicated that HFD-induced alterations in urinary, serum, and bone parameters as well as calcium homeostasis, all could be significantly ameliorated by BTE supplementation. Conclusion. Results suggest a potential role of BTE as a protective agent against NASH-induced changes in bone metabolism in rats. |
| format | Article |
| id | doaj-art-ebfdf5e273584abc87203c728fc4b4c3 |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-ebfdf5e273584abc87203c728fc4b4c32025-02-03T01:04:55ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/426863426863Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal DysfunctionSubhra Karmakar0Sangita Majumdar1Anasuya Maiti2Monalisa Choudhury3Aniruddha Ghosh4Asankur S. Das5Chandan Mitra6Pre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Tripura 799014, IndiaDepartment of Physiology, Presidency College, Kolkata, Kolkata, IndiaDepartment of Physiology, Presidency College, Kolkata, Kolkata, IndiaPre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Tripura 799014, IndiaDepartment of Physiology, Presidency College, Kolkata, Kolkata, IndiaPre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Tripura 799014, IndiaPre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Tripura 799014, IndiaAim. This paper aimed to examine the chemoprotective actions of aqueous black tea extract (BTE) against nonalcoholic steatohepatitis- (NASH-) induced skeletal changes in rats. Material. Wistar rats (body wt. 155–175 g) of both sexes, aged 4–5 months, were randomly assigned to 3 groups; Group A (control), Group B (60% high-fat diet; HFD), and Group C (HFD + 2.5% BTE). Methods. Several urinary (calcium, phosphate, creatinine, and calcium-to-creatinine ratio) serum (alkaline phosphatase and serum tartrate-resistant acid phosphatase), and molecular markers of bone turnover (receptor activator of NF-κB ligand (RANKL), osteoprotegerin (OPG), and estrogen) were tested. Also, several bone parameters (bone density, bone tensile strength, bone mineral content, and bone histology) and calcium homeostasis were checked. Results. Results indicated that HFD-induced alterations in urinary, serum, and bone parameters as well as calcium homeostasis, all could be significantly ameliorated by BTE supplementation. Conclusion. Results suggest a potential role of BTE as a protective agent against NASH-induced changes in bone metabolism in rats.http://dx.doi.org/10.4061/2011/426863 |
| spellingShingle | Subhra Karmakar Sangita Majumdar Anasuya Maiti Monalisa Choudhury Aniruddha Ghosh Asankur S. Das Chandan Mitra Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction Journal of Osteoporosis |
| title | Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction |
| title_full | Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction |
| title_fullStr | Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction |
| title_full_unstemmed | Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction |
| title_short | Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction |
| title_sort | protective role of black tea extract against nonalcoholic steatohepatitis induced skeletal dysfunction |
| url | http://dx.doi.org/10.4061/2011/426863 |
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