MCM7 promotes liver fibrosis by transcriptionally regulating IL11 via the SHCBP1-RACGAP1-STAT3 axis

MCM7 promotes liver fibrosis by transcriptionally regulating IL11 via the SHCBP1-RACGAP1-STAT3 axis

Abstract Liver fibrosis is driven by the persistent activation of hepatic stellate cells (HSCs) through inflammatory factors released from various cell types, including stressed hepatocytes, yet the underlying mechanisms are not fully understood. Here, we show that minichromosome maintenance complex...

Full description

Saved in:
Bibliographic Details
Main Authors: Cheng Wang, Mengling Ye, Tian Xu, Jiayi Feng, Jiaxi Zhang, Wenjuan Yang, Qian Fang, Guangbo Mei, Xuejun Zhao, Kejun Liu, Huiqin Zhou, Yaru Yu, Yujun Peng, Na Kuang, Xuebing Qiu, Qinping Zhong, Hongying Zong, Huifen Dong, Zhenping Ming, Yan Xiong, Rui Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07937-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41419-025-07937-x

Similar Items