Synergistic Integration of HDAC Inhibitors and Individualized Neoantigen Therapy (INT): A Next-Generation Combinatorial Approach for Cancer Immunotherapy

Synergistic Integration of HDAC Inhibitors and Individualized Neoantigen Therapy (INT): A Next-Generation Combinatorial Approach for Cancer Immunotherapy

Background: Cancer immunotherapy has advanced, yet therapeutic resistance and low response rates remain problematic. This study explores histone deacetylase inhibitors (HDACis) as adjuvants for cancer vaccines to enhance anti-tumor immunity and overcome these challenges. Methods: A comprehensive rev...

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Bibliographic Details
Main Authors: Rui Han, Huiling Zhou, Baoqing Peng, Shasha Yu, Jiajie Zhu, Jiaojiao Chen
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
histone deacetylase inhibitors
individualized neoantigen therapy (INT)
immunotherapy
antigen presentation
tumor microenvironment
Online Access:https://www.mdpi.com/2076-393X/13/6/550
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