Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway

Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway

Objective To investigate the mechanism by which cinnamaldehyde (CA) alleviates pulmonary arterial hypertension (PAH) through the TLR4/NF-kB/HIF-1a pathway.Methods PAH was induced in rats via SU5416 injection and hypoxia. Hemodynamics (RVMP, RVSP, mPAP) were measured. Histological changes were assess...

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Bibliographic Details
Main Authors: Jinbo Zhang, Wenxin Zhang, Zhiyong Yang, Bingbing Fan, Chunhe Wang, Zhengkun Tian
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Clinical and Experimental Hypertension
Subjects:
Cinnamaldehyde
pulmonary arterial hypertension
TLR4
endothelial dysfunction
vascular remodeling
Online Access:https://www.tandfonline.com/doi/10.1080/10641963.2025.2486829
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https://www.tandfonline.com/doi/10.1080/10641963.2025.2486829

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