Integrative analysis of m6A-SNPs and single-cell RNA sequencing reveals key drivers of endocrine combined with CDK4/6 inhibitor therapy resistance in ER+ breast cancer

Integrative analysis of m6A-SNPs and single-cell RNA sequencing reveals key drivers of endocrine combined with CDK4/6 inhibitor therapy resistance in ER+ breast cancer

BackgroundEndocrine therapy combined with CDK4/6 inhibitors remains a standard treatment for ER+ breast cancer, yet resistance is a prevalent challenge. This study explores the role of N6-methyladenosine (m6A) modifications, influenced by m6A-SNPs, in shaping therapy resistance, utilizing single-cel...

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Bibliographic Details
Main Authors: Ruijie Ming, Han Zhang, Huan Wu, Fangbiao Zhan, Xiaoping Huang, Huawen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
m6A methylation
single nucleotide polymorphism
CDK4/6 inhibitor
ER+ breast cancer
therapy resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590363/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1590363/full

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