Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities

Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities

Multiple myeloma (MM) remains an incurable hematologic malignancy due to the inevitable development of drug resistance, particularly in relapsed or refractory cases. Post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation, and glycosylation, play pivotal roles...

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Bibliographic Details
Main Authors: Shuoyang Hu, Jirun Xu, Weiyan Cui, Haoran Jin, Xiaoyu Wang, Yasen Maimaitiyiming
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
multiple myeloma
post-translational modifications
drug resistance
signaling pathways
tumor microenvironment
proteasome inhibitors (PIs)
Online Access:https://www.mdpi.com/2218-273X/15/5/702
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