Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth

Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth

Metastasis is the main cause of death from solid tumors. Therefore, identifying the mechanisms that govern metastatic growth poses a major biomedical challenge. Tumor microenvironment signals regulate the fate and survival of disseminated tumor cells (DTCs) in secondary organs. However, very little...

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Main Authors: L Recalde-Percaz, I de la Guia-Lopez, P Linzoain-Agos, A Noguera-Castells, M Rodrigo-Faus, P Jauregui, A Lopez-Plana, P Fernández-Nogueira, M Iniesta-González, M Cueto-Remacha, S Manzano, R Alonso, N Moragas, C Baquero, N Palao, E Dalla, FX Avilés-Jurado, I Vilaseca, X León-Vintró, M Camacho, G Fuster, J Alcaraz, J Aguirre-Ghiso, P Gascón, A Porras, A Gutiérrez-Uzquiza, N Carbó, P Bragado
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Neuropilins
dormancy
disseminated tumor cells
TGFβ
metastasis
breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000995
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