TLR3 rs3775291 C/T polymorphism is associated with elevated IFN-α level in asymptomatic HTLV-1 infection

TLR3 rs3775291 C/T polymorphism is associated with elevated IFN-α level in asymptomatic HTLV-1 infection

IntroductionAlterations in the immune response may influence the development of HTLV-1-associated diseases. TLR3 detects viral nucleic acids, including HTLV-1, and triggers the production of IFN-I and other cytokines. Genetic variations in TLR3 may alter the antiviral and inflammatory responses and...

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Main Authors: Fabiane dos Santos Ferreira, Wandrey Roberto dos Santos Brito, Emmanuelle Giuliana Mendes Santana, Aline Kelly Alves Oliveira, Aline Cecy Rocha de Lima, Ednelza da Silva Graça Amoras, Carlos Araujo da Costa, Maísa Silva Souza, Sandra Souza Lima, Ricardo Ishak, Izaura Maria Vieira Cayres-Vallinoto, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HTLV-I infection
inflammatory diseases
toll-like receptor 3
polymorphism genetic
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1604259/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1604259/full

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