Design and Synthesis of Pyridine-Based Pyrrolo[2,3-<i>d</i>]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-<i>d</i>]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

<b>Background/Objectives</b>: Colony stimulating factor 1 receptor kinase (CSF1R) is a well-validated molecular target in drug discovery for various reasons. Based on the structure of an early lead molecule identified in our lab and the marketed drug Pexidartinib (PLX3397), we merged fra...

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Main Authors: Srinivasulu Cherukupalli, Carsten Degenhart, Peter Habenberger, Anke Unger, Jan Eickhoff, Bård Helge Hoff, Eirik Sundby
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
CSF1R inhibitors
pyridine
pyrrolo[2,3-<i>d</i>]pyrimidine
scaffold hopping
molecular hybridization
Pexidartinib
Online Access:https://www.mdpi.com/1424-8247/18/6/814
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