Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth

Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth

Abstract Hypoxia frequently occurs during rapid tumour growth. However, how tumour cells adapt to hypoxic stress by remodeling central cellular pathways remains largely unclear. Here, we show that hypoxia induces casein kinase 2 (CK2)-mediated glucokinase (GCK) S398 phosphorylation, which exposes it...

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Main Authors: Gaoxiang Zhao, Shudi Luo, Hong Zhao, Qingxia Ma, Hongfei Jiang, Lin Wang, Juanjuan Liu, Dong Guo, Runze Wang, Qianqian Xu, Jie Lun, Ranran Xie, Yixin Duan, Leina Ma, Wensheng Qiu, Jing Fang, Zhimin Lu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62566-4
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https://doi.org/10.1038/s41467-025-62566-4

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