Enhancing Virus Filter Performance Through Pretreatment by Membrane Adsorbers

Enhancing Virus Filter Performance Through Pretreatment by Membrane Adsorbers

Virus filtration is used to ensure the high level of virus clearance required in the manufacture of biopharmaceutical products such as monoclonal antibodies. Flux decline during virus filtration can occur due to the formation of reversible aggregates consisting of self-assembled monomeric monoclonal...

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Bibliographic Details
Main Authors: Solomon Isu, Shu-Ting Chen, Raheleh Daneshpour, Hironobu Shirataki, Daniel Strauss, Andrew L. Zydney, Xianghong Qian, Sumith Ranil Wickramasinghe
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Membranes
Subjects:
aggregation
flux decline
fouling
membrane adsorber
monoclonal antibody
pH
Online Access:https://www.mdpi.com/2077-0375/15/1/34
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