Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide

Abstract Streptococcus mutans, the causative agent of human dental caries, expresses a cell wall attached Serotype c-specific Carbohydrate (SCC) that is critical for cell viability. SCC consists of a polyrhamnose backbone of →3)α-Rha(1 → 2)α-Rha(1→ repeats with glucose (Glc) side-chains and glycerol...

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Main Authors: Jeffrey S. Rush, Svetlana Zamakhaeva, Nicholas R. Murner, Pan Deng, Andrew J. Morris, Cameron W. Kenner, Ian Black, Christian Heiss, Parastoo Azadi, Konstantin V. Korotkov, Göran Widmalm, Natalia Korotkova
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56205-1
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