Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse

Background Tumor relapse constitutes a major challenge for anti-tumoral treatments, including immunotherapies. Indeed, most cancer-related deaths occur during the tumor relapse phase.Methods We designed a mouse model of tumor relapse in which mice transplanted with E7+ TC1 tumor cells received a sin...

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Bibliographic Details
Main Authors: Maxime Thoreau, Fabienne Regnier, Ludger Johannes, Estelle Dransart, Alain Trautmann, Nadege Bercovici, Marion v Guerin, Lene Vimeux, Matthieu Benard, Hweixian L Penny
Format: Article
Language:English
Published: BMJ Publishing Group 2020-10-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/2/e000996.full
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