Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review

The narrative review titled ‘Orbital Blood Flow and Pseudoexfoliation Syndrome’ provides a comprehensive exploration of the intricate interplay between pseudoexfoliation (PEX) syndrome and orbital blood flow, offering insights into its clinical ramifications. Commencing with an overview of the histo...

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Main Authors: Anujeet Paul, Aishwarya Naik, Prasanna V. Ramesh, Tamanna Ghosh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:TNOA Journal of Ophthalmic Science and Research
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Online Access:https://journals.lww.com/10.4103/tjosr.tjosr_91_24
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author Anujeet Paul
Aishwarya Naik
Prasanna V. Ramesh
Tamanna Ghosh
author_facet Anujeet Paul
Aishwarya Naik
Prasanna V. Ramesh
Tamanna Ghosh
author_sort Anujeet Paul
collection DOAJ
description The narrative review titled ‘Orbital Blood Flow and Pseudoexfoliation Syndrome’ provides a comprehensive exploration of the intricate interplay between pseudoexfoliation (PEX) syndrome and orbital blood flow, offering insights into its clinical ramifications. Commencing with an overview of the historical context and prevalence of PEX, the review traverses various dimensions, including gender and age considerations, mortality/morbidity rates, and the underlying pathophysiology. It delves into the composition of PEX material and delineates the differential gene expression associated with the syndrome. Central to the discourse is the impact of PEX on orbital vasculature, elucidating its correlation with ocular ischemia and alterations in protein levels within the aqueous humour. Techniques for clinical evaluation, notably colour Doppler imaging, emerge as indispensable tools for assessing blood flow in patients with PEX.The article emphasises the significance of vascular dysfunction in PEX, highlighting the findings of decreased blood flow velocities and elevated resistive indices in affected individuals.The review underscores the imperative of comprehending the vascular implications of PEX to optimise diagnostic and management approaches, with far reaching implications for minimising operative complications and enhancing patient outcomes.
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series TNOA Journal of Ophthalmic Science and Research
spelling doaj-art-eb40234a14514f55a90f326aa857a92d2025-01-16T07:06:10ZengWolters Kluwer Medknow PublicationsTNOA Journal of Ophthalmic Science and Research2589-45282589-45362024-12-0162440441110.4103/tjosr.tjosr_91_24Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative ReviewAnujeet PaulAishwarya NaikPrasanna V. RameshTamanna GhoshThe narrative review titled ‘Orbital Blood Flow and Pseudoexfoliation Syndrome’ provides a comprehensive exploration of the intricate interplay between pseudoexfoliation (PEX) syndrome and orbital blood flow, offering insights into its clinical ramifications. Commencing with an overview of the historical context and prevalence of PEX, the review traverses various dimensions, including gender and age considerations, mortality/morbidity rates, and the underlying pathophysiology. It delves into the composition of PEX material and delineates the differential gene expression associated with the syndrome. Central to the discourse is the impact of PEX on orbital vasculature, elucidating its correlation with ocular ischemia and alterations in protein levels within the aqueous humour. Techniques for clinical evaluation, notably colour Doppler imaging, emerge as indispensable tools for assessing blood flow in patients with PEX.The article emphasises the significance of vascular dysfunction in PEX, highlighting the findings of decreased blood flow velocities and elevated resistive indices in affected individuals.The review underscores the imperative of comprehending the vascular implications of PEX to optimise diagnostic and management approaches, with far reaching implications for minimising operative complications and enhancing patient outcomes.https://journals.lww.com/10.4103/tjosr.tjosr_91_24colour dopplerglaucomaorbital blood flowpseudoexfoliation
spellingShingle Anujeet Paul
Aishwarya Naik
Prasanna V. Ramesh
Tamanna Ghosh
Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review
TNOA Journal of Ophthalmic Science and Research
colour doppler
glaucoma
orbital blood flow
pseudoexfoliation
title Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review
title_full Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review
title_fullStr Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review
title_full_unstemmed Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review
title_short Orbital Blood Flow and Pseudoexfoliation Syndrome - A Narrative Review
title_sort orbital blood flow and pseudoexfoliation syndrome a narrative review
topic colour doppler
glaucoma
orbital blood flow
pseudoexfoliation
url https://journals.lww.com/10.4103/tjosr.tjosr_91_24
work_keys_str_mv AT anujeetpaul orbitalbloodflowandpseudoexfoliationsyndromeanarrativereview
AT aishwaryanaik orbitalbloodflowandpseudoexfoliationsyndromeanarrativereview
AT prasannavramesh orbitalbloodflowandpseudoexfoliationsyndromeanarrativereview
AT tamannaghosh orbitalbloodflowandpseudoexfoliationsyndromeanarrativereview