Thermostability Improvement of the Chitinase from <i>Bacillus circulans</i> for Efficient Chitin Oligosaccharide Production via Computational Design

Thermostability Improvement of the Chitinase from <i>Bacillus circulans</i> for Efficient Chitin Oligosaccharide Production via Computational Design

The chitinase A1 from <i>Bacillus circulans</i> WL-12 (BcChiA1) exhibits promising potential for producing chitin oligosaccharides (CHOs), while its application is limited by its poor thermal stability. In this study, a set of thermostable variants were obtained by modifying BcChiA1 usin...

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Bibliographic Details
Main Authors: Jingwei Liu, Jie Xie, Si Wang, Hong Feng, Ganggang Wang
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
chitinase
thermostability
computational design
chitin oligosaccharides
protein engineering
Online Access:https://www.mdpi.com/2218-273X/15/3/330
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