Pharmacogenetic aspects of the efficacy of nonsteroidal anti-inflammatory drugs and opioid analgesics for postoperative pain relief after total joint arthroplasty

Pharmacogenetic aspects of the efficacy of nonsteroidal anti-inflammatory drugs and opioid analgesics for postoperative pain relief after total joint arthroplasty

Objective: to investigate possible associations between genetic, clinical, laboratory, and demographic parameters and the level of pain in the early postoperative (p/o) period, the need for opioid analgesics, and gastrointestinal symptoms in patients who underwent primary total knee (TKR) or hip rep...

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Main Authors: A. S. Zhiryakova, N. P. Denisenko, S. N. Tuchkova, A. S. Petrukhina, A. V. Kryukov, I. V. Sychev, K. B. Mirzaev, O. V. Averkov, V. I. Vechorko, E. O. Filatov, D. A. Sychev
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2025-06-01
Series:Современная ревматология
Subjects:
total joint arthroplasty
postoperative pain
pain management
pharmacogenetics
nonsteroidal anti-inflammatory drugs
opioid analgesics
Online Access:https://mrj.ima-press.net/mrj/article/view/1773
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