Zika virus impairs non-homologous end joining and exacerbates DNA damage in neural progenitors derived from Huntington’s disease iPSCs via mutant huntingtin-elicited Ku70/Ku80 complex disruption
Abstract Background Zika virus (ZIKV) preferentially infects neural progenitor cells (NPCs) and is associated with NPC depletion in neonates. However, the impacts of ZIKV infection on NPCs in the context of neurodegenerative disease such as Huntington’s disease (HD) remains poorly understood. Method...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-025-04539-4 |
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