Zika virus impairs non-homologous end joining and exacerbates DNA damage in neural progenitors derived from Huntington’s disease iPSCs via mutant huntingtin-elicited Ku70/Ku80 complex disruption

Zika virus impairs non-homologous end joining and exacerbates DNA damage in neural progenitors derived from Huntington’s disease iPSCs via mutant huntingtin-elicited Ku70/Ku80 complex disruption

Abstract Background Zika virus (ZIKV) preferentially infects neural progenitor cells (NPCs) and is associated with NPC depletion in neonates. However, the impacts of ZIKV infection on NPCs in the context of neurodegenerative disease such as Huntington’s disease (HD) remains poorly understood. Method...

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Bibliographic Details
Main Authors: Feng-Lan Chiu, Jian-Jong Liang, Yi-Ling Lin, Hung-Chih Kuo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Zika virus
DNA damage
NHEJ
Mutant huntingtin
Huntington’s disease
Online Access:https://doi.org/10.1186/s13287-025-04539-4
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https://doi.org/10.1186/s13287-025-04539-4

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