Unraveling the development of cutaneous neurofibromas in neurofibromatosis type 1

Unraveling the development of cutaneous neurofibromas in neurofibromatosis type 1

Abstract Neurofibromatosis type 1 (NF1) is a genetic disorder that leads to the formation of cutaneous neurofibromas (cNFs), benign nerve sheath tumors that develop in the skin and significantly impact the quality of life of patients. cNF development begins with bi-allelic NF1 loss in the Schwann ce...

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Bibliographic Details
Main Authors: Pernelle Pulh, Fanny Coulpier, Audrey Onfroy, Layna Oubrou, Wanzhen Zhang, Léa Toledano, Elie Abou Zougheib, Laura Fertitta, Pierre Wolkenstein, Piotr Topilko
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Neurofibromatosis type 1
Cutaneous neurofibromas
Schwann cells
Fibroblasts
Fibrosis
Skin innervation
Online Access:https://doi.org/10.1186/s40478-025-02075-z
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https://doi.org/10.1186/s40478-025-02075-z

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