H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown. Here, western blot, and i...

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Bibliographic Details
Main Authors: Jiena Liu, Liuying Zhao, Meisi Yan, Shengye Jin, Lingmin Shang, Jianyu Wang, Qin Wang, Shilu Zhao, Zibo Shen, Tong Liu, Hao Wu, Da Pang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Lactylation
Glycolysis
Post-translational modifications
Epigenetic modification
Online Access:https://doi.org/10.1186/s13046-025-03512-6
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https://doi.org/10.1186/s13046-025-03512-6

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