Role of the Psi Packaging Signal and Dimerization Initiation Sequence in the Organization of Rous Sarcoma Virus Gag-gRNA Co-Condensates

Role of the Psi Packaging Signal and Dimerization Initiation Sequence in the Organization of Rous Sarcoma Virus Gag-gRNA Co-Condensates

Retroviral genome selection and virion assembly remain promising targets for novel therapeutic intervention. Recent studies have demonstrated that the Gag proteins of Rous sarcoma virus (RSV) and human immunodeficiency virus type-1 (HIV-1) undergo nuclear trafficking, colocalize with nascent genomic...

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Bibliographic Details
Main Authors: Gregory S. Lambert, Rebecca J. Kaddis Maldonado, Leslie J. Parent
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Viruses
Subjects:
retroviruses
Rous sarcoma virus
biomolecular condensates
genome selection
dimerization
Online Access:https://www.mdpi.com/1999-4915/17/1/97
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https://www.mdpi.com/1999-4915/17/1/97

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