SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma

SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma

Abstract Tumor-infiltrating myeloid cells (TIMs) are pivotal cell populations involved in the immunosuppressive tumor immune microenvironment (TIME). However, there has been little success in large-scale clinical trials of myeloid cell modulators. We aim to investigate potential molecular targets fo...

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Main Authors: Da Huang, Min Xu, Hui Wang, Yufei Zhao, Zihao Zhang, Mincheng Yu, Mingqin Zhou, Jingying Pan, Hong Zeng, Zichuan Yu, Qiang Yu, Mengyuan Wu, Wenxin Xu, Binghai Zhou, Bo Zhang, Hui Li, Lei Guo, Peiyi Xie
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07779-7
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https://doi.org/10.1038/s41419-025-07779-7

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