IGH rearrangements in Down syndrome acute lymphoblastic leukemia

IGH rearrangements in Down syndrome acute lymphoblastic leukemia

Background: The IGH locus is susceptible to translocations or insertions that contribute to B-cell precursor acute lymphoblastic leukemia (ALL) by ectopic or enhanced expression of a gene relocated to the IGH enhancer. The frequency of IGH rearrangements is relatively high in Down syndrome (DS) ALL....

Full description

Saved in:
Bibliographic Details
Main Authors: Naomi Michels, Jade Admiraal, Aurélie Boeree, Edwin Sonneveld, Anthony V. Moorman, Gabriele Escherich, Rosemary Sutton, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer, Judith M. Boer
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EJC Paediatric Oncology
Subjects:
Fluorescence in situ hybridization
Pediatric
Down syndrome
RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X25000108
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2772610X25000108

Similar Items