HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.

HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.

During meiosis, chromosomes align with their homologous pairing partners and stabilize this alignment through assembly of the synaptonemal complex (SC). Since the SC assembles cooperatively yet is indifferent to homology, pairing and SC assembly must be tightly coordinated. We identify HAL-2 as a ke...

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Main Authors: Weibin Zhang, Natasha Miley, Michael S Zastrow, Amy J MacQueen, Aya Sato, Kentaro Nabeshima, Enrique Martinez-Perez, Susanna Mlynarczyk-Evans, Peter M Carlton, Anne M Villeneuve
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002880&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002880&type=printable

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