Endothelial protein C receptor promotes retinal neovascularization through heme catabolism

Endothelial protein C receptor promotes retinal neovascularization through heme catabolism

Abstract Pathological retinal neovascularization (RNV) is one of the leading causes of blindness worldwide; however, its underlying mechanism remains unclear. Here, we found that the expression of endothelial protein C receptor (Epcr) was increased during RNV, and its ligand was elevated in the seru...

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Main Authors: Hongyuan Song, Qing Li, Xiao Gui, Ziyu Fang, Wen Zhou, Mengzhu Wang, Yuxin Jiang, Ajun Geng, Xi Shen, Yongxuan Liu, Haorui Zhang, Zheng Nie, Lin Zhang, Huimin Zhu, Feng Zhang, Xuri Li, Fanyan Luo, Hongjian Zhang, Wei Shen, Xiaodong Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56810-0
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https://doi.org/10.1038/s41467-025-56810-0

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