Stem cell-derived exosomes prevent the development of thoracic aortic aneurysm/dissection by inhibiting AIM2 inflammasome and pyroptosis

Stem cell-derived exosomes prevent the development of thoracic aortic aneurysm/dissection by inhibiting AIM2 inflammasome and pyroptosis

Thoracic aortic aneurysm/dissection (TAAD) is a severe vascular condition associated with life-threatening complications, and its underlying molecular mechanisms remain largely unexplored. Previous research indicates that the aberrant activation of cytosolic DNA and its receptors plays a crucial rol...

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Bibliographic Details
Main Authors: Lin Lu, Feng Liu, Weiliang Wu, Yu Zhang, Bin Liu, Qingfang Han, Tonggan Lu, Huiling Zhang, Xi-yong Yu, Yangxin Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Extracellular Vesicle
Subjects:
AIM2
Thoracic aortic aneurysm/dissection
Inflammation
Deubiquitinating enzymes
Exosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2773041724000131
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