Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine.

Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine.

In order to evaluate the role of persisting virus replication during occult phase immunisation in the live attenuated SIV vaccine model, a novel SIVmac239Δnef variant (SIVrtTA) genetically engineered to replicate in the presence of doxycycline was evaluated for its ability to protect against wild-ty...

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Bibliographic Details
Main Authors: Neil Berry, Maria Manoussaka, Claire Ham, Deborah Ferguson, Hannah Tudor, Giada Mattiuzzo, Bep Klaver, Mark Page, Richard Stebbings, Atze T Das, Ben Berkhout, Neil Almond, Martin P Cranage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006083&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006083&type=printable

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