Super‐Enhancer Driven LIF/LIFR‐STAT3‐SOX2 Regulatory Feedback Loop Promotes Cancer Stemness in Head and Neck Squamous Cell Carcinoma

Super‐Enhancer Driven LIF/LIFR‐STAT3‐SOX2 Regulatory Feedback Loop Promotes Cancer Stemness in Head and Neck Squamous Cell Carcinoma

Abstract Super‐enhancers (SEs) have been recognized as key epigenetic regulators underlying cancer stemness and malignant traits by aberrant transcriptional control and promising therapeutic targets against human cancers. However, the SE landscape and their roles during head and neck squamous cell c...

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Bibliographic Details
Main Authors: Jin Li, Yuhan Wang, Ziyu Wang, Yuxiang Wei, Pengfei Diao, Yaping Wu, Dongmiao Wang, Hongbing Jiang, Yanling Wang, Jie Cheng
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
cancer stem cells
head and neck squamous cell carcinoma
leukemia inhibitory factor
stemness
super‐enhancer
Online Access:https://doi.org/10.1002/advs.202404476
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https://doi.org/10.1002/advs.202404476

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