Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis
ObjectiveWhile growing evidence supports the Geriatric Nutritional Risk Index (GNRI) as a prognostic indicator for various cancers, its predictive value in pancreatic cancer remains unclear. This meta-analysis systematically evaluates GNRI’s ability to predict postoperative complications and long-te...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1464447/full |
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| author | Yaqi Hua Yaqi Hua Yi Yuan Chen Zhou Chen Zhou Liping Liu Yan Hu Ping Tu Dongying Li |
| author_facet | Yaqi Hua Yaqi Hua Yi Yuan Chen Zhou Chen Zhou Liping Liu Yan Hu Ping Tu Dongying Li |
| author_sort | Yaqi Hua |
| collection | DOAJ |
| description | ObjectiveWhile growing evidence supports the Geriatric Nutritional Risk Index (GNRI) as a prognostic indicator for various cancers, its predictive value in pancreatic cancer remains unclear. This meta-analysis systematically evaluates GNRI’s ability to predict postoperative complications and long-term outcomes in pancreatic cancer patients.MethodsWe conducted a comprehensive literature search across nine databases (Web of Science, PubMed, Embase, Cochrane Library, Scopus, WanFang, CNKI, VIP, and SinoMed) through June 1, 2025. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to assess overall survival (OS), while risk ratios (RRs) with 95% CIs evaluated postoperative complications.ResultsFrom 233 initially identified studies, 10 met inclusion criteria (n = 2,003 patients). Pooled analysis revealed that lower GNRI significantly predicted worse OS (HR = 1.92, 95% CI 1.54–2.41, p < 0.0001) and higher postoperative pancreatic fistula (POPF) incidence (RR = 0.18, 95% CI 0.08–0.43, p < 0.001). No significant association was found between GNRI and post-pancreatectomy hemorrhage (PPH) (RR = 0.21, 95% CI 0.03–1.53, p = 0.13).ConclusionGNRI shows promise as a clinically useful predictor of OS and POPF in pancreatic cancer patients. However, these findings require validation through prospective multicenter studies.Systematic review registrationIdentifier CRD42023409362. |
| format | Article |
| id | doaj-art-ea477a124bee4563be5438b1cf8a6eb0 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-ea477a124bee4563be5438b1cf8a6eb02025-08-20T03:56:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-07-011210.3389/fnut.2025.14644471464447Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysisYaqi Hua0Yaqi Hua1Yi Yuan2Chen Zhou3Chen Zhou4Liping Liu5Yan Hu6Ping Tu7Dongying Li8Department of Intensive Care Unit, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaSchool of Nursing, Jiangxi Medical College, Nanchang University, Nanchang, ChinaSchool of Nursing, University of South China, Hengyang, Hunan, ChinaDepartment of Intensive Care Unit, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaSchool of Nursing, Jiangxi Medical College, Nanchang University, Nanchang, ChinaNursing Department, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaWound Ostomy Clinic, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Post Anesthesia Care Unit, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Intensive Care Unit, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaObjectiveWhile growing evidence supports the Geriatric Nutritional Risk Index (GNRI) as a prognostic indicator for various cancers, its predictive value in pancreatic cancer remains unclear. This meta-analysis systematically evaluates GNRI’s ability to predict postoperative complications and long-term outcomes in pancreatic cancer patients.MethodsWe conducted a comprehensive literature search across nine databases (Web of Science, PubMed, Embase, Cochrane Library, Scopus, WanFang, CNKI, VIP, and SinoMed) through June 1, 2025. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to assess overall survival (OS), while risk ratios (RRs) with 95% CIs evaluated postoperative complications.ResultsFrom 233 initially identified studies, 10 met inclusion criteria (n = 2,003 patients). Pooled analysis revealed that lower GNRI significantly predicted worse OS (HR = 1.92, 95% CI 1.54–2.41, p < 0.0001) and higher postoperative pancreatic fistula (POPF) incidence (RR = 0.18, 95% CI 0.08–0.43, p < 0.001). No significant association was found between GNRI and post-pancreatectomy hemorrhage (PPH) (RR = 0.21, 95% CI 0.03–1.53, p = 0.13).ConclusionGNRI shows promise as a clinically useful predictor of OS and POPF in pancreatic cancer patients. However, these findings require validation through prospective multicenter studies.Systematic review registrationIdentifier CRD42023409362.https://www.frontiersin.org/articles/10.3389/fnut.2025.1464447/fullgeriatric nutritional risk indexpancreatic cancerprognosissurvivalmeta-analysis |
| spellingShingle | Yaqi Hua Yaqi Hua Yi Yuan Chen Zhou Chen Zhou Liping Liu Yan Hu Ping Tu Dongying Li Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis Frontiers in Nutrition geriatric nutritional risk index pancreatic cancer prognosis survival meta-analysis |
| title | Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis |
| title_full | Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis |
| title_fullStr | Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis |
| title_full_unstemmed | Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis |
| title_short | Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis |
| title_sort | predictive value of geriatric nutritional risk index in patients with pancreatic cancer a meta analysis |
| topic | geriatric nutritional risk index pancreatic cancer prognosis survival meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1464447/full |
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