miR-1246 enhances chemo-resistance of polyploid giant cancer cells in H1299 cells by targeting GSK3β/β-catenin

miR-1246 enhances chemo-resistance of polyploid giant cancer cells in H1299 cells by targeting GSK3β/β-catenin

Abstract Non-small cell lung cancer (NSCLC) is characterized by a high mortality rate. Chemotherapy has been observed to potentially increase the prevalence of polyploid giant cancer cells (PGCCs), which may play a role in the development of chemo-resistance in NSCLC. The dysregulated expression of...

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Bibliographic Details
Main Authors: Lili Wang, Zien Yang, Sining Xing, Song Zhao, Mingyue Ouyang, Huiying Yu
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Non-small cell lung cancer
Polyploid giant cancer cells
miR-1246
GSK3β
β-catenin
Chemo-resistance
Online Access:https://doi.org/10.1007/s12672-025-02756-0
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