Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation

Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation

Abstract Background Microglia-evoked neuroinflammation contributes to neurodegenerative diseases such as multiple sclerosis (MS). Metabolic reprogramming, including changes in polyunsaturated fatty acids (PUFAs), plays a critical role in MS pathophysiology. Previous studies identified reduced plasma...

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Bibliographic Details
Main Authors: Xiao-Xi Zhu, Pei-Juan Wang, Shan Chao, Wei-Jia Tang, Long-You Zhao, Li-Mei Yu, Fan Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Ferroptosis
NF-κB signaling
α-dimorphecolic acid
Microglial inflammation
Multiple sclerosis
Metabolomics
Online Access:https://doi.org/10.1186/s12967-025-06296-7
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https://doi.org/10.1186/s12967-025-06296-7

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