USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells

USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells

Abstract Ubiquitin-specific peptidase 18 (USP18) is a specific interferon-stimulated gene 15 demodifying enzyme that plays an important role in apoptosis. In this study, we investigated the role of USP18 in apoptosis in hepatocellular carcinoma cells, especially its ability to regulate apoptosis thr...

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Bibliographic Details
Main Authors: Lin Li, Nana Liu, Pujuan Yang, Chunyan Rao, Lingna Kong, Yi Huang, Qingsong Lei, Huabao Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Ubiquitin-specific peptidase 18
Apoptosis
Endoplasmic reticulum stress
Hepatocellular carcinoma
Protein kinase RNA-like Endoplasmic reticulum kinase
Online Access:https://doi.org/10.1038/s41598-025-00540-2
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https://doi.org/10.1038/s41598-025-00540-2

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