External validation of the Oncotype DX breast cancer recurrence score nomogram and development and validation of a novel machine learning-based model to predict postoperative overall survival and guide adjuvant chemotherapy in ER positive, Her-2 negative breast cancer patients: a retrospective cohort study

External validation of the Oncotype DX breast cancer recurrence score nomogram and development and validation of a novel machine learning-based model to predict postoperative overall survival and guide adjuvant chemotherapy in ER positive, Her-2 negative breast cancer patients: a retrospective cohort study

BackgroundThis study aims to externally validate the performance of the Oncotype DX (ODX) breast cancer (BC) recurrence score nomogram in predicting adjuvant chemotherapy (ACT) for BC after surgery and subsequently develop a machine learning-based model to predict postoperative overall survival (OS)...

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Bibliographic Details
Main Authors: Dongdong Wang, Xinfeng Wang, Xin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
breast cancer
machine learning
prognostic model
guidance for adjuvant chemotherapy
web calculator
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1586262/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1586262/full

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