Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design
Abstract VHHs (also known as nanobodies) are important therapeutic antibodies. To prolong their half‐life in bloodstream, VHHs are usually fused to the Fc fragment of full‐length antibodies. However, stability is often the main challenge for their commercialization, and methods to improve stability...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202500004 |
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