The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
Idiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs include dermatomyositis, inclusion body myositis, immune-mediated necrotizing myopathy, and polymyositis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1455867/full |
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| author | Julie J. Paik Lisa Christopher-Stine Mikael Boesen Mikael Boesen John A. Carrino S. Peter Eggleton Deborah Denis Olga Kubassova |
| author_facet | Julie J. Paik Lisa Christopher-Stine Mikael Boesen Mikael Boesen John A. Carrino S. Peter Eggleton Deborah Denis Olga Kubassova |
| author_sort | Julie J. Paik |
| collection | DOAJ |
| description | Idiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs include dermatomyositis, inclusion body myositis, immune-mediated necrotizing myopathy, and polymyositis (PM). PM is increasingly recognized as a rare subtype and often included in overlap myositis, the antisynthetase syndrome when no rash is present, or misdiagnosed inclusion body myositis. Magnetic resonance imaging (MRI) has played an increasingly important role in IIM diagnosis and assessment. Although conventional MRI provides qualitative information that is helpful for diagnosis, its application for the quantitative assessment of disease activity is challenging. Therefore, advanced quantitative MRI techniques have been implemented in the past 10 years to highlight potential new applications of disease monitoring in IIM. The aim of this review is to examine the role of quantitative MRI techniques in evaluating the key imaging features of IIM, mainly muscle edema and muscle damage (fatty replacement and/or muscle atrophy). |
| format | Article |
| id | doaj-art-ea1fcd698f7c47aa8e70a33797603b47 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ea1fcd698f7c47aa8e70a33797603b472025-01-27T06:40:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14558671455867The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping reviewJulie J. Paik0Lisa Christopher-Stine1Mikael Boesen2Mikael Boesen3John A. Carrino4S. Peter Eggleton5Deborah Denis6Olga Kubassova7Department of Myositis, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Myositis, Johns Hopkins University, Baltimore, MD, United StatesIAG, Image Analysis Group, London, United KingdomDepartment of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, DenmarkDepartment of Radiology and Imaging, Weill Cornell Medicine, Hospital for Special Surgery, New York, NY, United StatesGlobal Clinical Development, Merck Serono Ltd., Feltham, United Kingdom, an affiliate of the healthcare business of Merck KGaAGlobal Clinical Development, EMD Serono Research & Development Institute, Inc., Billerica, MA, United States, an affiliate of the healthcare business of Merck KGaAIAG, Image Analysis Group, London, United KingdomIdiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs include dermatomyositis, inclusion body myositis, immune-mediated necrotizing myopathy, and polymyositis (PM). PM is increasingly recognized as a rare subtype and often included in overlap myositis, the antisynthetase syndrome when no rash is present, or misdiagnosed inclusion body myositis. Magnetic resonance imaging (MRI) has played an increasingly important role in IIM diagnosis and assessment. Although conventional MRI provides qualitative information that is helpful for diagnosis, its application for the quantitative assessment of disease activity is challenging. Therefore, advanced quantitative MRI techniques have been implemented in the past 10 years to highlight potential new applications of disease monitoring in IIM. The aim of this review is to examine the role of quantitative MRI techniques in evaluating the key imaging features of IIM, mainly muscle edema and muscle damage (fatty replacement and/or muscle atrophy).https://www.frontiersin.org/articles/10.3389/fimmu.2025.1455867/fulldermatomyositisidiopathic inflammatory myopathiesmagnetic resonance imagingmyositispolymyositis |
| spellingShingle | Julie J. Paik Lisa Christopher-Stine Mikael Boesen Mikael Boesen John A. Carrino S. Peter Eggleton Deborah Denis Olga Kubassova The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review Frontiers in Immunology dermatomyositis idiopathic inflammatory myopathies magnetic resonance imaging myositis polymyositis |
| title | The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review |
| title_full | The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review |
| title_fullStr | The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review |
| title_full_unstemmed | The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review |
| title_short | The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review |
| title_sort | utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies a scoping review |
| topic | dermatomyositis idiopathic inflammatory myopathies magnetic resonance imaging myositis polymyositis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1455867/full |
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