The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review

Idiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs include dermatomyositis, inclusion body myositis, immune-mediated necrotizing myopathy, and polymyositis...

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Main Authors: Julie J. Paik, Lisa Christopher-Stine, Mikael Boesen, John A. Carrino, S. Peter Eggleton, Deborah Denis, Olga Kubassova
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1455867/full
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author Julie J. Paik
Lisa Christopher-Stine
Mikael Boesen
Mikael Boesen
John A. Carrino
S. Peter Eggleton
Deborah Denis
Olga Kubassova
author_facet Julie J. Paik
Lisa Christopher-Stine
Mikael Boesen
Mikael Boesen
John A. Carrino
S. Peter Eggleton
Deborah Denis
Olga Kubassova
author_sort Julie J. Paik
collection DOAJ
description Idiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs include dermatomyositis, inclusion body myositis, immune-mediated necrotizing myopathy, and polymyositis (PM). PM is increasingly recognized as a rare subtype and often included in overlap myositis, the antisynthetase syndrome when no rash is present, or misdiagnosed inclusion body myositis. Magnetic resonance imaging (MRI) has played an increasingly important role in IIM diagnosis and assessment. Although conventional MRI provides qualitative information that is helpful for diagnosis, its application for the quantitative assessment of disease activity is challenging. Therefore, advanced quantitative MRI techniques have been implemented in the past 10 years to highlight potential new applications of disease monitoring in IIM. The aim of this review is to examine the role of quantitative MRI techniques in evaluating the key imaging features of IIM, mainly muscle edema and muscle damage (fatty replacement and/or muscle atrophy).
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series Frontiers in Immunology
spelling doaj-art-ea1fcd698f7c47aa8e70a33797603b472025-01-27T06:40:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14558671455867The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping reviewJulie J. Paik0Lisa Christopher-Stine1Mikael Boesen2Mikael Boesen3John A. Carrino4S. Peter Eggleton5Deborah Denis6Olga Kubassova7Department of Myositis, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Myositis, Johns Hopkins University, Baltimore, MD, United StatesIAG, Image Analysis Group, London, United KingdomDepartment of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, DenmarkDepartment of Radiology and Imaging, Weill Cornell Medicine, Hospital for Special Surgery, New York, NY, United StatesGlobal Clinical Development, Merck Serono Ltd., Feltham, United Kingdom, an affiliate of the healthcare business of Merck KGaAGlobal Clinical Development, EMD Serono Research & Development Institute, Inc., Billerica, MA, United States, an affiliate of the healthcare business of Merck KGaAIAG, Image Analysis Group, London, United KingdomIdiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity. The classic subgroups in IIMs include dermatomyositis, inclusion body myositis, immune-mediated necrotizing myopathy, and polymyositis (PM). PM is increasingly recognized as a rare subtype and often included in overlap myositis, the antisynthetase syndrome when no rash is present, or misdiagnosed inclusion body myositis. Magnetic resonance imaging (MRI) has played an increasingly important role in IIM diagnosis and assessment. Although conventional MRI provides qualitative information that is helpful for diagnosis, its application for the quantitative assessment of disease activity is challenging. Therefore, advanced quantitative MRI techniques have been implemented in the past 10 years to highlight potential new applications of disease monitoring in IIM. The aim of this review is to examine the role of quantitative MRI techniques in evaluating the key imaging features of IIM, mainly muscle edema and muscle damage (fatty replacement and/or muscle atrophy).https://www.frontiersin.org/articles/10.3389/fimmu.2025.1455867/fulldermatomyositisidiopathic inflammatory myopathiesmagnetic resonance imagingmyositispolymyositis
spellingShingle Julie J. Paik
Lisa Christopher-Stine
Mikael Boesen
Mikael Boesen
John A. Carrino
S. Peter Eggleton
Deborah Denis
Olga Kubassova
The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
Frontiers in Immunology
dermatomyositis
idiopathic inflammatory myopathies
magnetic resonance imaging
myositis
polymyositis
title The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
title_full The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
title_fullStr The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
title_full_unstemmed The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
title_short The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review
title_sort utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies a scoping review
topic dermatomyositis
idiopathic inflammatory myopathies
magnetic resonance imaging
myositis
polymyositis
url https://www.frontiersin.org/articles/10.3389/fimmu.2025.1455867/full
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