α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy

α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy

Lipid nanoparticles (LNPs) have emerged as a clinically validated platform for cancer immunotherapy; however, challenges remain in optimizing RNA delivery and promoting synergistic immune activation. To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (...

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Bibliographic Details
Main Authors: Kexin Zhang, Zhen Xu, Zexiu Xiao, Fei Cao, Jing Wang, Yuandong Xu, Winson M.J. Ma, Sihui Long, Gao-Feng Zha
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Lipid nanoparticles
α-GalCer
Natural killer T
mRNA vaccine
Cancer immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425004533
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