Therapeutic Challenges and Emerging Strategies for <i>T674I</i> and <i>PTPN11</i> Mutations in a <i>FIP1L1-PDGFRA</i>-Positive Myeloproliferative Neoplasm: A Case Report

Therapeutic Challenges and Emerging Strategies for <i>T674I</i> and <i>PTPN11</i> Mutations in a <i>FIP1L1-PDGFRA</i>-Positive Myeloproliferative Neoplasm: A Case Report

Myeloproliferative neoplasm (MPN) with eosinophilia associated with <i>FIP1L1-PDGFRA</i> is a rare eosinophilic disorder typically treated with imatinib. However, resistance due to the T674I mutation poses a significant challenge. This case presents the first reported instance of concurr...

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Bibliographic Details
Main Authors: Sıdıka Gülkan Özkan, Ali Kimiaei, Seyedehtina Safaei, Mutlu Karkucak, Mustafa Nuri Yenerel, Aslı Yüksel Öztürkmen, Burak Alp, Hasan Atilla Özkan
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Life
Subjects:
eosinophilic disorder
<i>FIP1L1-PDGFRA T674I</i> mutation
imatinib resistance
<i>PTPN11</i> mutation
myeloproliferative neoplasm
Online Access:https://www.mdpi.com/2075-1729/15/3/505
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