A head-to-head comparison of S100B and GFAP/UCH-L1 for detection of traumatic intracranial lesions in a Scandinavian trauma cohort

A head-to-head comparison of S100B and GFAP/UCH-L1 for detection of traumatic intracranial lesions in a Scandinavian trauma cohort

Abstract Background Few countries recommend glial fibrillary protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a substitute for S100 astroglial calcium-binding protein B (S100B) in early detection of traumatic intracranial lesions in mild TBI (mTBI). This study aims to evaluate the cl...

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Bibliographic Details
Main Authors: Thea Overgaard Wichmann, Ayad Babaee, Kirsten Duch, Mikkel Mylius Rasmussen, Maj Lesbo, Ole Brink, Lars C. Borris, Claus V. B. Hviid
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Subjects:
Mild traumatic brain injury (mTBI)
Glial fibrillary acidic protein (GFAP)
S100 astroglial calcium-binding protein B (S100B)
Ubiquitin C-terminal hydrolase-L1 (UCH-L1)
Online Access:https://doi.org/10.1186/s13049-025-01364-9
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https://doi.org/10.1186/s13049-025-01364-9

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