Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes

Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes

Abstract Background Colorectal cancer (CRC) presents significant treatment challenges due to its high heterogeneity and complex intercellular interactions. Further exploration of CRC subtypes and interactions among tumor-specific clusters will facilitate the development of personalized treatment str...

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Main Authors: Youpeng Wang, Xingfeng Qiu, Qinghai Li, Jiale Qin, Lvlan Ye, Xiang Zhang, Xingxiang Huang, Xiangqiong Wen, Ziyang Wang, Weiling He, Yuqin Di, Qi Zhou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Single-cell RNA sequencing
Cancer-associated fibroblast (CAF)
Chemoresistance
Online Access:https://doi.org/10.1186/s12967-025-06103-3
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https://doi.org/10.1186/s12967-025-06103-3

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