Cell Homeostasis or Cell Death—The Balancing Act Between Autophagy and Apoptosis Caused by Steatosis-Induced Endoplasmic Reticulum (ER) Stress

Cell Homeostasis or Cell Death—The Balancing Act Between Autophagy and Apoptosis Caused by Steatosis-Induced Endoplasmic Reticulum (ER) Stress

Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver condition with potential progression to cirrhosis and impaired regeneration post-resection. A key mechanism underlying lipotoxicity is endoplasmic reticulum (ER) stress, particularly the activation of the unfolded...

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Bibliographic Details
Main Authors: Anna Stilkerich, Gerda Schicht, Lena Seidemann, René Hänsel, Adrian Friebel, Stefan Hoehme, Daniel Seehofer, Georg Damm
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
unfolded protein response
ER stress
hepatic lipid metabolism
MASLD
liver regeneration
primary human hepatocytes
Online Access:https://www.mdpi.com/2073-4409/14/6/449
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